| 학회 |
한국고분자학회 |
| 학술대회 |
2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
47권 1호 |
| 발표분야 |
대학원생 구두발표(발표15분) |
| 제목 |
Polysaccharide Derivative-based Multifunctional Coating of Intravascular Catheters: A Simple and Biocompatible Method to Improve Antimicrobial and Antithrombotic Activities |
| 초록 |
Antimicrobial, antithrombotic activity and low-friction properties are indispensable for the surface of intravascular catheters (ICs). In this study, we proposed a strategy that fabrication of multifunctional ICs by eco-friendly and biocompatible modification method. IC was coated with multifunctional polysaccharide, O-carboxymethyl chitosan (O-CMC). O-CMC coating layer was adapted to be porous (micro- and nanoscale), creating superhydrophilic property. Especially, the superhydrophilic surface exhibited outstanding anti-adhesion performance of Escherichia coli and platelet. Anti-adhesion performance could be synergistic effect along with intrinsic antimicrobial and antithrombotic properties of O-CMC. Furthermore, we verified the low-friction property of porous O-CMC coated IC via measurement of coefficient of friction under continuous wet friction conditions. We further demonstrated the excellent trackability of actual IC that applied proposed coating strategy. |
| 저자 |
박세계1, 신재학2, 정재희2, 최동윤1, 이동윤3, 유승화4
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| 소속 |
1한국생산기술(연), 2세종대, 3경북대, 4전북대 |
| 키워드 |
Polysaccharide; Intravascular catheters; Antimicrobial activity; Antithrombotic activity; Low-friction
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| E-Mail |
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