| 초록 |
Synthetic biology has been providing innovative solutions for pressing challenges. Our ability to design biological systems by synthetic biology is dependent on how to regulate gene expression. Nucleic acids open new avenues for developing artificial gene regulators owing to the programmability, versatility, low genetic footprint, and economic production both in vivo and in vitro. In this talk, I am going to present examples showing how rational design and combinatorial approaches can cooperate to develop nucleic acid-based artificial gene regulators for metabolic engineering and molecular diagnosis. Specifically, an efficient development process for RNA-based gene regulators and their applications for microbe-based chemical production will be discussed. Then, a rationally designed nucleic acid-based system for the diagnosis of pathogens called SENSR will be presented. |
