| 초록 |
Cyclodextrins(CDs) are a series of cyclic oligosaccharides consisting of 6-8 glucose units connected by α-1,4 linkages and used as drug delivery carriers to increase the aqueous solubility of poorly water-soluble drugs, and to increase their bioavailability and stability. Stimuli responsive polymers sensitive to external temperature, light or pH are of increasing interests because of their potential applications in biomedical field. In this work, stimuli responsive triblock copolymers were synthesized by the polymerization of n-isopropyl acrylamide(NIPAAm) by ATRP with pseudo polyrotaxane initiator, in which many β-CDs were threaded onto a poly(propylene glycol). Their lower critical solution temperatures (LCST) were determined by cloud point measurements over a range of pH environments. The structure of the resulting copolymers was characterized in various instruments |
