| 초록 |
Cancer recurrence and metastasis after tumor resection surgery remains a significant cause of treatment failure. To address these limitations, implantable drug delivery systems have been extensively researched. Since cationic polysaccharides have mucoadhesion, and blood hemostasis properties, they have been considered as promising biomaterials in drug delivery. In addition, cationic polysaccharides are a type of natural adjuvants, thus can induce dendritic cell activation to promote Thelper1 cell immune responses, macrophage activation, and cytokine production. Based on the above-mentioned outcomes, we demonstrate the feasibility of multifunctional hydrogels with controlled release of anti-cancer drugs as local drug delivery for effective cancer therapy. Thus, the hydrogel was able to suppress a secondary recurrence and metastasis of the tumor. Taken all together, we believe that the multifunctional hydrogel can improve immunotherapeutic efficacy with minimized side effects. |
