| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Preparation and evaluation of Doxorubicin-loaded Redox-Sensitive polymeric micelles for Therapy Cancer |
| 초록 |
Number of researcher developed to drug carrier in order to delivery of hydrophobic drug in cancer cell. However, they have a problem that led to sustained drug release in tumor site. To solve these problem, we used to lipoic acid (LA) and it was introduced to back bone of water soluble chitosan by coupling agent. Structural analysis of LA-grafted water soluble chitosan (LWC) was accomplished by 1H-NMR and FT-IR. Its critical aggregation concentration (CAC) was analyzed by fluorophotometer. Also, Doxorubicin (DOX)-loaded LWC (DLWC) nanoparticles were prepared by dialysis method. The drug contents and drug efficiency from DLWC was obtained by using UV-vis spectrophotometer. To demonstrate redox-sensitive effect of DLWC, drug release behavior was accomplished in presence GSH. Moreover, cytotoxicity conducted by using MTT assay. These results suggest that redox-sensitive LWC can apply as carrier for drug delivery. (NRF-2016H1D5A1910499) |
| 저자 |
안준혁1, 정은희1, 홍웅길1, 정경원1, 박준규2, 나재운1
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| 소속 |
1순천대, 2(주) 시지바이오 |
| 키워드 |
water soluble Chitosan; Lipoic acid; Doxorubicin; redox-sensitive
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| E-Mail |
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