| 학회 | 한국화학공학회 |
| 학술대회 | 2005년 가을 (10/21 ~ 10/22, 인하대학교) |
| 권호 | 11권 2호, p.2008 |
| 발표분야 | 지속가능형 화학소재생산 |
| 제목 | Epoxide hydrolase-catalyzed enantioselective and enantioconvergent hydrolysis for production of enantiopure epoxides and diols |
| 초록 | Enantiopure epoxides and diols are valuable synthetic intermediates for preparing more complex enantiopure pharmaceuticals. Enantiopure epoxides can be produced by enantioselective hydrolysis of racemic epoxides using epoxide hydrolases (EHs). EHs are cofactor-independent enzymes that convert epoxides to their corresponding diols by addition of a water molecule to the oxirane ring. Some EHs have been shown to have complementary enantioselectivity exhibiting opposite regioselectivity on the two enantiomers of racemic epoxide substrates, indicating that a 100% yield of enantiopure diol with high enantiopurity of up to 100% ee can be prepared by enantioconvergent process. In this presentation, we report on our recent works on enantioselective and enantioconvergent hydrolysis of racemic epoxides using various EHs from miroorganisms, fish and marine bioresources to produce enantiopure epoxides and diols. Acknowledgment: This work was supported by the Marine and Extreme Genome Research Center Program, Ministry of Marine Affairs and Fisheries, Republic of Korea. |
| 저자 | 이은열, 김희숙 |
| 소속 | 경성대 |
| 키워드 | enantiopure epoxides; enantiopure diol; epoxide hydrolase; enantioselective hydrolysis; enantioconvergent process |
| 원문파일 | 초록 보기 |
