| 초록 |
Non-invasive sample collection for early diagnosis is significant in today's aging society. Saliva, containing pathological and physiological biomarkers, may be collected patient-friendly, enabling easier access for patients with diabetes or hemophilia. Concentrations of markers in saliva correlate with them in blood, which makes it a promising candidate for biosensing. Salivary biosensors have widely been studied, but current tests have restrictions like showing low specificity and requiring professional labor. In this study, a platform is 3D-printed with biocompatible materials, integrated with non-toxic sponges for simple saliva loading and direct delivery through channels. In detection zone, hydrogel patterned and framed nanofibers are incorporated. Detection of biomarkers may be proceeded by enzymatic reactions resulting in distinguishable color changes. Furthermore, SERS techniques is applied for sensitive measurements and quantifications of salivary oncology markers. |
