| 초록 |
Anisotropic polypeptide structures with distinct nanoscaled compartments have been of growing interest for biomedical applications. Recently, electrohydrodynamic (EHD) co-jetting of multiple polymer solutions with a side-by-side geometry has been used for the synthesis of anisotropic polymer nanostructures. We are specifically interested in environmentally-responsive elastin-like polypeptides (ELPs) because (1) they undergo an inverse phase transition in aqueous conditions at lower critical solution temperature (LCST), and (2) they are genetically engineered and purified by non-chromatographic method at large scale. In this study, we report various anisotropic ELP nanostructures with environmental responsiveness prepared by EHD co-jetting and their biomedical applications. Conceptually, this work could establish a facile platform methodology to prepare anisotropic polypeptide nanostructures for smart drug delivery, tissue engineering, regenerative medicine, and molecular imaging. |
