| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
PSK-FAPS 2018 Congress on Functional Polymers and Their Applications (English) |
| 제목 |
Application of Biodegradable Organogel from Microbial Monomer in Topical Drug Delivery |
| 초록 |
In this study biodegradable polyester organogel was developed from oil palm empty fruit bunch (OPEFB) derived monomers and oleic acid for pharmaceutical purpose. Enzymatic polymerization was conducted to synthesis biodegradable polyester using succinic acid that was microbially synthesized from OPEFB cellulose. 4-Hydroxybenzoic acid monomer was produced from OPEFB lignin by using enzymatic hydrolysis process. Oleic acid was used as a lipid phase in the system and also as a penetration enhancer whereas curcumin was used as a model of hydrophobic drug. The polymer organogel was closely monitored and thermal, rheological and mechanical properties were compared with the established organogel for their potential use as an effective topical drug carrier. The organogel showed pseudoplastic rheological features, with excellent mechanical properties (firmness, adhesiveness, and compressibility), which indicated their excellent spreadability for application on skin. Stability of organogels was determined by physical assessment at 4 °C, 25 °C, and 40 °C and the drug content (curcumin) was determined with High Performance Liquid Chromatography (HPLC). Polymer organogel (PBSO) that was prepared from a mixture of 4-hydoxybenzoic acid and poly(butylene glycol succinate) showed the highest drug loading content compared to other organogels. It is therefore concluded that the produced polyester organogel could be used as an effective topical drug delivery vehicle for pharmaceutical purposes. |
| 저자 |
Satriani Aga Pasma, Rusli Daik, Mohd Hanif Zulfakar, Suria Ramli, Mohamad Yusof Maskat
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| 소속 |
Universiti Kebangsaan Malaysia |
| 키워드 |
organogel; biopolymer; topical drug delivery; curcumin; lignin; cellulose
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| E-Mail |
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