| 초록 |
The aim of this study is to overcome solubility of celecoxib, so we prepared solid dispersion for improvement of dissolution rate by using spray dryer. It was formulated by using pH dependent polymer with Eudragit E100 and hydrophilic polymer with poly-vinyl-pyrrolidone(PVP). Also this study demonstrated the influence of citric acid. Characterization of solid dispersion was analyzed by using SEM, DSC, XRD and FT-IR. SEM and FT-IR was used to alalyze morphology and salt formation by chemical bond between celecoxib and polymer. DSC and XRD were used to analyze both the amorphous and crystal field of solid dispersions. in vitro release behavior of solid dispersion presented in simulated gastric juice (pH 1.2). The dissolution rate of solid dispersion was higher than commercial drug (Celebrex®). This study suggest that the rate of added polymers effect the dissolution rate and solid dispersion system improved of the bioavailability of drug. This research was supported by WCU (R31-20029). |
