| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Densely Iodinated Stealth Dendrimers as High-Performance Contrast Agents for X-Ray Computed Tomography Imaging |
| 초록 |
Small-molecule iodinated contrast media are often injected intravenously as radiopaque agents during CT imaging to achieve high contrast enhancement for vascular systems. The rapid excretion rate of these agents is overcome by injecting a significantly high dose of iodine, which can have serious side effects. Here we report a simple and scalable method to prepare high-performance blood-pool contrast agents for CT via a straightforward two-step synthesis from dendrimers for the first time using tetraiodobenzene derivatives as potent radiopaque moieties. Excellent in vivo safety has been demonstrated for these small (13-22 nm) unimolecular water-soluble dendritic contrast agents, which exhibit high contrast enhancement in the blood-pool and effectively extend their blood half-lives. Our method is applicable to virtually any scaffold with suitable surface groups and may fulfill the current need for safer, next-generation iodinated CT contrast agents. |
| 저자 |
김윤경 |
| 소속 |
한국생명공학(연) |
| 키워드 |
dendrimers; computed tomography; contrast agents; medical imaging
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| E-Mail |
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