| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
[화학물질안전·위해성] 유해화학물질의 안전성과 위험성 평가 |
| 제목 |
Synergistic activation of estrogen receptor alpha by two biocides with different substances in consumer chemical products in HeLa9903 cells |
| 초록 |
Much of the substances widely used inconsumer chemical products are known as estrogenic endocrine-disruptingchemicals. Further, when they are exposed to receptors together, theinteraction, i.e., antagonism, additivity, and synergism, between chemicalsshould be considered, but relevant experimental data are still lacking. Forthis reason, high-throughput screening of 352chemicals and their binary mixtures were tested using HeLa9903 with miniaturing modification of OECD TG 455 forestrogenic effect. As a result, we found two kinds of biocides act as synergists. Most combinations with those two biocidal substances showover 2-fold more substantial estrogenic effects than expected. If these twochemicals co-expose in addition to the baseline effect from chemicals in ourdaily life, more severe estrogenic activity can perturb thehomeostasis of the endocrine system. Validation studies in in vivo and epidemiologicalobservations should be warranted. |
| 저자 |
김선미, 정대영, 김현영, 박우규, 조희영, 김종운
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| 소속 |
한국화학(연) |
| 키워드 |
Estrogenic effect; Mixture; Consumer chemical products; Biocides
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| E-Mail |
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