| 초록 |
Herein, we report a fluid-resistant adhesive intraperitoneal (IP) patch that seals intestinal neo-anastomosis sites, preventing anastomotic leakage after colorectal surgery. Dressing with IP patches reliably seals intestinal incision sites, resulting in significant reduction of anastomotic leakage after colorectal surgery. Additionally, IP patches can act as unprecedented local drug reservoirs due to the tissue adhesive property. Drug-loaded IP patches successfully treated multiple-site occurrence of small peritoneal cancerous colonies. Thus, the multi-functionality of IP patches can be usefully exploited as an adhesive biomaterial that works effectively in difficult-to-treat diseases observed in intraperitoneal environments. |
