| 초록 |
Work presented here describes an innovative approach for the bioapplication of the hierarchically ordered nanoporous materials to smart drug delivery system. This is a very simple and flexible approach to control the drug-release on the nanometer scale of ordered linear porous channels and L3-phase (sponge-phased) hybrid nanogel based on tailoring network of thermosensitive polymer, poly(N-isopropylacrylamide (PNIPAm). Sustainable positive drug release profile is obtained and the drug slowly diffuses out of the porous channels. The overall release rate can be adjusted by changing the composition of the nanogel. The drug release showed a sustained positive thermosensitive release profile by suggested nanodiffusion mechanism in which the overall release amount was controlled by changing the pore channel size. The efficiency of drug-loaded and drug-release were calculated by solid state UV-Vis. spectrophotometric method comapared the unmodified and PNIPAm-modified nanoporous materials with various pore sizes. |
