| 학회 |
한국재료학회 |
| 학술대회 |
2019년 봄 (05/15 ~ 05/17, 평창 알펜시아 리조트) |
| 권호 |
25권 1호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Fabrication, in vitro and in vivo evaluation of the effect of hyaluronic acid-supplemented porous Bioglass granules based injectable bone substitute for enhanced cellular interactions and bone regeneration. |
| 초록 |
Bioactive stimulation and spatiotemporal evolution of porous scaffolds with time are critical for accelerating the bone regeneration process. In recent years, granule-type bioactive glass scaffolds have been taken an interest in biomedical applications. 45S5 bioglass is well known for their excellent biocompatibility and for an abroad range of successful applications in tissue regeneration as well as in both hard and in soft tissues. The dissolution products and bioactive surfaces of the bioglass materials have extensive effects on bone cell activity. In this study, we attempt to fabricate highly initial porous bioglass granules to enhance new bone tissue ingrowth. However, granules implantation are required complicated and invasive surgery as they are prone to scatter in the implant site for their low weight and lack of cohesive nature. On the other hand, injectable bone substutite (IBS) provides a minimal invasive application in filling bone cracks and irregular size defects. Therefore, an injectable bone substitute fabricated by incorporating hyaluronic acid as a binder to the interconnected bioglass granules was investigated to evaluate the performance of bone tissue regeneration. The uncoated and coated porous bioglass granules were characterized by X-ray diffraction (XRD) and FTIR for composition, scanning electron microscopy for morphology and bioactivity in the simulated body fluid (SBF), and porosity analysis for porosity and pore size determination. In vitro and in vivo experiment will be conducted to assess the biocompatibility and bone regeneration. |
| 저자 |
Le Thi Thanh Thao1, Lee Byong Taek2
|
| 소속 |
1Institute of medical science, 2Soonchunhyang Univ. |
| 키워드 |
Injectable bone substitute; 45S5 bioglass; hyaluronic acid; porous granules
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| E-Mail |
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