| 초록 |
The main function of bone cement is to stabilize prosthesis by filling the gap between the prosthesis and the surrounding bone and to transmit loads from the prosthesis the bone. PMMA bone cement, which was widely used in orthopedic surgery, has no ability for bone bonding, leading to aseptic loosening of the cement. To overcome these disadvantages, several bioactive bone cements with high bioactivity and improved physical properties have been developed. In the present study, we have prepared the novel organic-inorganic hybrid bioactive bone cements containing both Bis-GMA derivatives (3MA and 4MA) as prepolymer and inorganic fillers (AW-GC and β-TCP). As compared with Bis-GMA control, new bioactive 3MA bone cements with an appropriate matrix ratio showed proper curing time, low polymerization shrinkage, low water absorption and solubility as well as high mechanical properties. In addition, surface morphology of 3MA bone cements was observed after 2 days incubation in simulated body fluid (SBF) solution and their cytotoxicity was evaluated using the agar overlay method.
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