| 초록 |
As an effort for developing a high rate bioreactor that provides high productivity along with high concentration of lactic acid, the performance of membrane cell-recycle bioreactor (MRB) was investigated with experimental studies. Due to greatly increased cell density, high lactic acid productivity, 21.6 gL-1h-1, was obtained in the reactor. The lactic acid concentration, however, could not be increased higher than 83 g/L. When an additional CSTR (continuous stirred tank reactor) was attached next to the MRB a higher lactic acid concentration of 87 g/L was produced at a significant expense of the productivity. When the two MRBs were connected in series, 92 g/L lactic acid could be produced with a productivity of 57 gL-1h-1, the highest productivity among the reports of L(+)-lactic acid that obtained lactic acid concentration higher than 85 g/L using glucose substrate. |
