| 초록 |
Localized administration is essential for therapy of inner ear disorders because of dense ‘blood-labyrinth barrier’ which drugs can't penetrate via systemic injection. Among numerous drug carriers based on polymers, injectable hydrogels can be useful for direct injection of drugs. But these can be easily washed out from the target due to their frictional failure. Here, we developed mucoadhesive granular hydrogels with great injectability, low ototoxicity as well as sustained release of drugs for long-term treatment. The microgels consist of hyaluronic acid hydrogel ‘core’ covalently crosslinked via thiol-en reaction and mucoadhesive ‘shell’ through polymerization of catecholamine monomers (dopamine and norepinephrine). The jammed mucoadhesive microgels encapsulating dexamethasone as a model drug could be easily injected using 29 G needles. Our approach to engineer highly injectable and mucoadhesive granular hydrogel would be a promising strategy for localized inner ear delivery. |
