| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Alginate-coated thiolated chitosan microsphere for an oral drug delivery system |
| 초록 |
Thiolated polymers are reported to have mucoadhesive property owing to thiol bearing side chains. Thiomers mimic the natural mechanism of secreted mucus glycoproteins, which are also covalently anchored in the mucus layer by the formation of disulfide bonds-the bridging structure most commonly encountered in biological systems. In this study, thiolated chitosan microspheres (TCMs) were prepared by ionic gelation process with tripolyphosphate and then, the bovine growth hormone (BGH) as a model drug was loaded. Finally, the BGH-loaded TCMs (bTCMs) was coated with alginate to improve the stability of drug-loaded microspheres in gastrointestinal (GI) track. The alginate-coated bTCMs were observed as spherical shapes. The average particle size of alginate-coated bTCMs was 2.69±0.39 µm and the size-distribution was shown uniformly. Also, effects of several formulation factors on drug release according to concentration of drug and alginate concentration were investigated. |
| 저자 |
강호림, Rohidas Arote, 유미경, 김인용, 최윤재, 조종수
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| 소속 |
서울대 |
| 키워드 |
Alginate; thiolated chitosan microsphere; oral drug delivery system
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| E-Mail |
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