| 학회 |
한국화학공학회 |
| 학술대회 |
2018년 가을 (10/24 ~ 10/26, 대구 EXCO) |
| 권호 |
24권 2호, p.1517 |
| 발표분야 |
생물화공(Biochemical Engineering) |
| 제목 |
Transcriptomics analysis of Escherichia coli W mutant tolerant to high concentration of3-hydroxypropionic acid |
| 초록 |
3-Hydroxypropionic acid (3-HP) is an important platform chemical which can be produced from glycerol by recombinant Escherichia coli. One of the challenges for commercialization of 3-HP production is its toxic effect at high concentration. Recently, a novel transcriptional regulator (designated as 3HPT) was found to be related with 3-HP tolerance in E. coli. However, the mechanism of its regulation is still unknown. To address this issue, transcriptome analysis of several E. coli W mutants which is highly tolerant to 3-HP was conducted. Interestingly, there was more than hundreds of genes are regulated by 3HPT. Among them, many genes are related with acid tolerance mechanisms, some genes have not been well studied. Functional analysis and further experiments to elucidate the mechanism are in progress. |
| 저자 |
Phu Nguyen-Vo Thuan1, Yunxiao Liang2, Mugesh Sankaranarayanan3, Eunhee Seol4, Ah Yeong Chun5, Somasundar Ashok6, Ashish Chauhan7, Jung-Rae Kim8, Sunghoon Park9
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| 소속 |
1부산대, 2School of Chemical and Biomolecular Engineering, 3Pusan National Univ., 4Busan 46241, 5Korea, 6School of Energy and Chemical Engineering, 7UNIST, 8Ulsan 44919, 9Korea / School of Chemical and Biomolecular Engineering |
| 키워드 |
생물화공 |
| E-Mail |
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| 원문파일 |
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