| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
[생체재료] 바이오메디컬 헬스케어를 위한 지속성장 가능한 바이오소재 혁신 |
| 제목 |
Anti-senescence nanocarrier for enhancing therapeutic properties of high passaged stem cells |
| 초록 |
Human adipose‑derived stem cells (hADSCs) have been used in various fields of tissue engineering because of their promising therapeutic efficacy. To facilitate the use of long‑term‑cultured hADSCs (L‑ADSCs), we designed a novel therapeutic anti‑senescence ion‑delivering nanocarrier (AIN) that is capable of recovering the therapeutic properties of L‑ADSCs. In the present study, we introduced a low‑pH‑responsive ion nanocarrier capable of delivering transition metal ions that can enhance angiogenic paracrine factor secretion from L‑ADSCs. This study suggests a novel method and strategy for cell‑based tissue regeneration that can overcome the limitations of the low stemness and therapeutic efficacy of stem cells that occurs during long‑term cell culture. |
| 저자 |
방석호 |
| 소속 |
성균관대 |
| 키워드 |
Anti-senescence; Nano material; Stem cell
|
| E-Mail |
|
