| 초록 |
At the interface of an implanted neural probe, immune responses inevitably limit the recording performance of the device. To prevent these negative actions, we designed and fabricated titanium substrates covered with cell membranes which were extracted from differentiated PC12 cells to induce the surface localization of neural cell adhesion molecules, which promotes neurite outgrowth and neural network formation. The surface modification was investigated with FT-IR, confocal laser scanning microscopy observation and fluorescence recovery after photo-bleaching (FRAP) assay. Further, in vitro cell study revealed encouraging results in terms of adhesion and differentiation of neuronal cells, showing different behaviors of astrocytes from those of neuronal cells. In conclusion, our study demonstrates that this approach may act as an efficient tool for modulating immune responses derived from neural probe. |
