| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Neuronal cell membrane immobilized on neural interface devices for competent tissue integration |
| 초록 |
After implanting neural probes, immune responses inevitably limit the performance of the device. As a promising solution to this dilemma, we designed and fabricated titanium substrates covered with cell membranes extracted from differentiated PC12 cells to induce the surface adhesion of neural cell molecules, thus promoting neurite outgrowth and neural network formation on the surface. The modified substrates were prepared by pre-tethering of lipids on the surface of titanium and introducing extracted membrane components onto that as a membrane-like bilayer structure by vesicle fusion method. Successful surface modifications were confirmed via FT-IR, confocal laser scanning microscopy observation and fluorescence recovery after photo-bleaching (FRAP) assays. Furthermore, in vitro cell study revealed that the surface specifically encouraged adhesion and differentiation of neural cells when compared to astrocytes. |
| 저자 |
Mahmoud amr Elnaggar, 김가을, 정윤기, Goeen Jeong, 임충만, Md Lemon Hasan, Myoung-Ryul OK
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| 소속 |
한국과학기술(연) |
| 키워드 |
tissue integration |
| E-Mail |
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