| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Controlled Release Behavior of Nifedipine from Squeeze-Type Tablet in Osmotic Delivery System |
| 초록 |
Osmotic delivery systems are based on osmotic deriving force. Nifedipine tablets, available under the trade names of Procardia XL® (Pfizer) and Adalat® (Bayer), are commercialized drug-delivery systems of an elemental osmotic pump that the pushpull osmotic tablet operates successfully in delivering water-insoluble drugs. For the improvement of the release pattern and the solubility of the drug, we developed a squeeze-type osmotic tablet (SQT) for nifedipine as a model drug. The SQT was composed of one or more ring type of squeeze-push layer (squeeze-disc) and a centered drug core. Squeeze-discs were stacked up with different physicochemical properties with gradient such as viscosity, swelling ratio and water absorption ratio using the osmotic agents from a disc of bottom to top. This research was supported by WCU(R31-20029). |
| 저자 |
이은용, 김원, 김수진, 이종문, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
Osmotic; Controlled Release; Nifedipine
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| E-Mail |
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