| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Intervertebral Disc Regeneration Using Stem Cell/Growth Factor/LSS Microparticle System |
| 초록 |
It has been reported that 80% of the human population experiences intervertebral disc degeneration (IDD) which caused by dehydration of nucleus pulposus surrounded by annulus fibrosus. The nucleus pulposus largest avascular tissue (oxygen level 1 to 5%) in the body mainly consists of water, proteoglycans, and nucleus pulposus cells with chondrocytic phenotype. In recent years, human bone marrow-derived mesenchymal stem cells (hBMSCs) which can be differentiated in multi-lineage have been widely adapted to reconstruct the nucleus pulposus and reduce IDD. In this study, we fabricated growth factor-loaded microparticles with leaf-stacked structure (LSS microparticles) which can allow sustained release of the growth factor. hBMSCs were also seeded on the microparticles for the effective treatment of IDD. The growth factor release behavior and chondrogenic differentiation of the hBMSCs were investigated. |
| 저자 |
김민지1, 이재훈2, 김준수2, 이진호3, 오세행1
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| 소속 |
1단국대, 2경상대, 3한남대 |
| 키워드 |
Intervertebral disc; Microparticle; Leaf-stacked structure; hMSC; Growth factor
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| E-Mail |
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