| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Intervertebral Disc Regeneration Using Stem Cell/Growth Factor-Loaded Porous Microparticles |
| 초록 |
Low back pain which restricts daily life and has a high incidence/prevalence is a major health problem. Major cause of the low back pain is understood by intervertebral disc degeneration (IDD) caused by dehydration or herniation of nucleus pulposus. The nucleus pulposus mainly consists of water and a proteoglycan-rich extracellular matrix and cells with chondrocytic phenotype. In recent years, human bone marrow-derived mesenchymal stem cells (hBMSCs) which can be differentiated into chondrogenic cell-type have been widely adapted to treat IDD. In this study, we fabricated a growth factor-loaded microparticle with leaf-stacked structure which can allow sustained release of the TGF-β3. hBMSCs were also seeded on the microparticle for the effective treatment of IDD. The growth factor release behavior, chondrogenic differentiation of the hBMSCs, and intervertebral disc regeneration using beagle dog animal model were investigated. |
| 저자 |
김민지1, 정영조2, 이재훈3, 김준수3, 이진호2, 오세행1
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| 소속 |
1단국대, 2한남대, 3경상대 |
| 키워드 |
Intervertebral disc; stem cell; growth factor; micro particle
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| E-Mail |
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