| 초록 |
Bone fractures are treated with bioceramic based materials such as biphasic calcium phosphate (BCP) scaffolds. BCP is an attractive choice as bone substitute for not only possessing similar mineral composition to bone but also having excellent biocompatibility, degradability, and osteoconductive property. Herein, porous BCP scaffolds were loaded with foamed soya-gelatin hydrogel to improve strength of the scaffold whereas hydrogel was optimized by 10% soya with 5% gelatin. In addition, soya is known for its osteogenic and macrophage modulating property. The pore size of the BCP scaffold ranged from 200-320 µm while soya-gelatin hydrogel loaded BCP scaffold micropore size ranged from 10-40 µm and macropore size ranged from 220-320 µm. The compressive strength of the BCP scaffold, soya-gelatin hydrogel, and hydrogel/BCP scaffolds were 0.386 ± 0.03 MPa, 2.574 ± 0.029 MPa, and 2.711 ± 0.065 MPa respectively. The protein foamed scaffold would have sufficient mechanical strength, and would possess both osteoconductive and osteoinductive properties, which are essential considerations for bone substitutes. |
