| 초록 |
Silicone hydrogel contact lense is well known as a high oxygen permeability because of the affinity of the internal silicon atom and oxygen molecule. However, silicon atoms in the lense are usually present in the form of siloxanes, thereby increasing hydrophobicity and deteriorating biocompatibility. To compensate these disadvantages, surface modification was attempted to enhance hydrophilicity of the lens but the surfaces are not persisted. In this study, new monomers of siloxane with permanently hydrophilic groups were synthesized with high purity and high yield through thiol-ene click reaction of multifunctional vinyl silicone monomers and thiol compounds having hydrophilic groups. Silicone hydrogel contact lense was prepared through bulk copolymerization with conventional hydrophilic monomers and the new siloxane monomers, and then oxygen permeability, water content, and contact angle were measured to evaluate their physical properties according to the content of the silicon atom. |
