| 초록 |
Multifunctional nanomedicine holds considerable promise as the next generation of medicine that will enable early detection of diseases, as well as simultaneous monitoring and therapy with minimal toxicity. In particular, surface-enhanced Raman scattering (SERS) technology with high sensitivity and multiplexing capabilities is emerging as a powerful alternative for identifying specific biological targets in live cells. In this study, we synthesized a novel SERS pattern “hyaluronic acid (HA) based gold nanochain”. We demonstrate a simple method to assemble citrate-stabilized gold nanoparticles into nanochains within a few seconds by using HA. An efficient photosensitizer (PS)-pheophorbide A was introduced to the nanochain as Raman reporter and anticancer drug for cancer diagnosis and therapy. The optical property and morphology of HA based gold nanochains were investigated. In vitro tests using HeLa cells indicated that the HA based nanochain had excellent cellular localization and killed HeLa cells effectively compare to free Pheo under laser radiation. |
