| 초록 |
Understanding the effects of microenvironmental characteristics on tumor cell migration is important for the development of new anti-migratory therapies. Indeed, an importat problem in studying cell motility in vitro is the difficulty in reproducing the native behavior of these tumor cells, and over-simplified in vitro culture systems may lead to inaccurate results regarding the efficacy of drugs. Here, I will introduce the tumor microenvironment array platform (T-MAP), which mimics the both biochemical and mechanophysical microenvironment of gliblastoma multiforme. The engineered platform, mimicking the brain tissue, induced the native characteristics and behavior of glioma cells by micro-environmental cues. Using the T-MAP, we demonstrated the potential for screening anti-cancer drugs by inhibiting associated signaling pathways on GBM cells. |
