| 초록 |
Platinum(IV)-based anticancer drugs have exhibited enormous potential as cancer therapeutics by overcoming the drawbacks of conventional Platinum (II)-based ones. Moreover, the axial position of Pt(IV) provides two reaction sites for the crosslinking of two molecules. We present a Pt(IV)-based polymer structure for synergistic siRNA and cisplatin delivery. To achieve this, low molecular weight polyethylenimines (PEIs) were crosslinked by the axial position of Pt(IV), and subsequent conjugation of poly ethylenglycol (PEG) was conducted to formulate the polymer structure (Pt-PEI-PEG). The Pt-PEI-PEG exhibited redox-responsive dissociation of polymers and the simultaneous release of active Pt(II) drug, resulting in faster gene release as well as high drug efficacy. Efficient delivery of siRNA using Pt-PEI-PEG was demonstrated in cellular level. By employing siBcl-2 which enhances the apoptosis caused by anticancer drugs, synergistic therapeutic effect of cisplatin and siRNA was monitored. |
