| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
콜로이드·계면화학_포스터 |
| 제목 |
O2-Nanobubble of Iron-Porphyrin conjugated Polyaspartamide for Molecular Ultrasound contrast effect |
| 초록 |
A number of nanoscale self-assemblies have been extensively used in various biomedical and industrial application such as targeted delivery carrier for diagnosis and therapy. In this study, we prepared the oxygen-nanobubble containing ferrous porphyrins to mimic the ability of porphyrin of hemoglobin in red blood cell to gather oxygen. First, we synthesized poly(2-hydroxyethyl aspartamide)(PHEA) grated with ferrous porphyrins, which could form self-assemblies in an aqueous solution. Then, the nanobubble was formed as liposomal bubble using 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine and the ferrous porphyrin-conjugated PHEA was self-assembled to induce the oxygen inside bubble. The nanobubbles were maintained less than 1 μm of diameter and stable spherical form by modulating degree of substitution of porphyrin as 5mol%. Further, the nanobubble containing the ferrous porpytin and oxygene showed enhanced photoacoustic effect as ultrasound contrast agent via the Doppler ultrasound test. |
| 저자 |
오승주1, 한사라1, 김희진1, 한병희2, 정재현1
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| 소속 |
1숭실대, 2고려대 |
| 키워드 |
Poly(aspartamide); Iron-Porpyrin; Oxygne uptake; Self-assembly; Ultrasound Imaging
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| E-Mail |
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