| 초록 |
Bio-microelectromechanical systems (Bio-MEMS) have great potential as tools for various tissue engineering, typically applied in in vitro cell culture models with the development of microfluidic devices. In this study, Bio-MEMS, namely Bio-Circuit, which could simultaneous cell culture and selective physiological stimulated. These multi-functionalized polymers were designed for enabling water-soluble, cross-linking of the hydrogel, polymerization to polypyrrole, and cell adhesion. These Bio-Circuits were characterized in terms of various degrees of substitutions, the surface density of the conductive unit, pattern thicknesses, and electrode distances. Also, the C2C12 myotubes on Bio-Circuit have exhibited muscle contraction through selective stimuli of the signaling pathway. Thus, a new strategy to prepare Bio-Circuits using multivalent poly(aspartamide) could assist a wide array of applications with Organ-On-a-Chip, Bio-MEMS, Bio-robot, and other devices for tissue engineering. |
