| 초록 |
Polymer-directed crystallization has been studied in the pharmaceutical research and development areas because various properties can be manipulated. Polymer-directed crystallization can generate crystal formation via nonclassical routes, i.e., crystallization mediated by the physical adsorption of long chain molecules. This study aims to prepare composite crystals of two drugs, celecoxib (Cel) and quercetin (Qu) using the polymer-directed crystallization. Changes in crystal morphology of Cel and Qu were investigated by optical microscopy (OM) and scanning electron microscope (SEM). X-ray diffraction (XRD) observed no changes in the crystalline forms. The melting point measurements by Differential Scanning Calorimetry (DSC) showed that the melting points of the two drugs were significantly depressed, indicating significant interactions among the drugs and polymers. This novel preparation method of composite crystals could offer a new opportunity to produce complex formulations. |
