| 학회 | 한국공업화학회 |
| 학술대회 | 2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 | 22권 1호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | Injectable Taurine-loaded Alginate Hydrogels for Retinal Pigment Epithelium (RPE) Regeneration |
| 초록 | Injectable hydrogels have fabricated by ionic cross-linking method and the representative injectable hydrogel is alginate. Taurine acts as a neurotransmitter in the retina and stabilizes the structure of the retina. In this study, we conduct an injectable taurine (Tr)-loaded alginate (Agn) hydrogels that can treat AMD (Age-related macular degeneration). Porosity, swelling and fourier transform infrared spectroscopy were measured to evaluate the mechanical, physical and chemical properties of the scaffolds. Cell proliferation and migration were improved in Tr/Agn hydrogels and these cells were highly expressed the RPE-specific mRNA. The scaffolds transplanted under the subcutaneous were exhibited excellent biocompatibility and biodegradability. Collectively, the injectable Tr/Agn hydrogels have the potential for the treatment of retinal diseases such as AMD. Acknowledgment: This research was supported by Basic Science Research Program (NRF-2017R1A2B3010270) |
| 저자 | 신은영, 박종호, 김한솔, 최민정, 강길선 |
| 소속 | 전북대 |
| 키워드 | RPE; Tissue engineering; Alginate; Taurine; Injectable |
