| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Characterization of Biocompatibility Alginate-SIS Sponge |
| 초록 |
Small intestinal submucosa(SIS) is the natural biomaterials mainly composed of collagen, glycosaminoglycan and growth factors. Tissue engineering techniques have been investigated the possibility of the application of SIS for a wound dressing. SIS solutions of 1 and 2 wt% with 0.1% pepsin in 3% acetic acid were reacted for 48 hrs and freeze-dried. They were treated with different concentrations (50, 100 mM and 200 mM) of EDC for 24 hrs and lyophilzed. Then 1 wt% alginate solution was pass through the SIS sponge and lyophilzed. Calcium chloride was used as crosslinking agent. The prepared sponges were characterized by scanning electron microscopy. The biocompatibility of NIH/3T3 with these SIS sponges was found to be acceptable at a cell. We investigated biodegradation of SIS sponge, MTT assay. From the MTT assay results, the biocompatibility of the crosslinked SIS sponge with NIH/3T3 was confirmed. |
| 저자 |
송인범1, 홍금덕1, 이민숙1, 강길선1, 김문석2, 이해방2
|
| 소속 |
1전북대, 2한국화학(연) |
| 키워드 |
small intestinal submucosa; biocompatibility; cross-linked; sponge
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| E-Mail |
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