| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Controlled Synthesis of Mesoporous Calcium Silicates with Ultrahigh Drug/Protein Loading Capacity and Their pH-Triggered Release Behaviors |
| 초록 |
We have developed a facile method for the synthesis of mesoporous calcium silicates (CS) using PAH i.e. CS-PAH with a large specific surface area (SBET = 348.4 m2g-1) and pore volume (Vp=1.42 cm-3g-1). TEOS was employed as silicon source, which rapidly hydrolyzes and reacts with amine groups of PAH and Ca2+ to form nanosheets as building blocks in basic media. The excess of Ca2+ enriches the surfaces and results in well-defined 3D network structures of CS-PAH. Ibuprofen (IBU) and FITC labeled bovine serum albumin were chosen as a model drug and protein respectively for testing loading and delivery proficiency of CS-PAH. Ultrahigh DLC and the linear relationship between cumulative amounts of their released have been found under controlled pH conditions. Excitingly, the highest DLC reported so far 3.1 mg IBU in per mg carrier achieved. Also CS-PAH can entirely transform to hydroxyapatite after the drug release in simulated body fluid (SBF), implying the good bioactivity. |
| 저자 |
샤히눌1, 이하진2, 최원산1
|
| 소속 |
1KBSI, 2jeonju center |
| 키워드 |
mesoporous calcium silicate; drug delivery; controlled release; biodegradable |
| E-Mail |
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