| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Preparation of mimicking natural extracellular matrix electrospun sheet using small intestinal submucosa (SIS) |
| 초록 |
The uses of electrospun micro/nanofiber sheet have been raising scientific influences because of its potential to mimic natural extracellular matrix (ECM). In this study, small intestinal submucosa (SIS) blended poly(caprolactone-co-lactide(PCLA) nanofiber sheets was successfully electrospun in various conditions and polymer concentrations. Therefore, it opens the ability to control production of nanofiber sheets with physical and biological properties that similar to those of natural ECM. Characterization of fiber morphology by scanning electron microscope (SEM) and biodegradation test suggested the significant impact of SIS concentration on fiber size and biodegradation rate of the SIS nanofiber sheet. MTT assay showed that the SIS electrospun sheet was highly biocompatible. We confirmed that the drug loaded in SIS/PCLA nanofiber sheet released sustainably. In further study, we hypothesize that SIS/PCLA electrospun sheet is an ideal candidate for drug delivery system. |
| 저자 |
김문석1, 백지혜1, 박지훈1, Nguyen Thi Thu Thao2
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| 소속 |
1아주대, 2epartment of Molecular Science and Technology |
| 키워드 |
Small intestinal submucosa (SIS); Electrospinning; Nanofiber sheet; Drug delivery system.
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| E-Mail |
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