| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Preparation and Characterization of Anti-oxidant agent-encapsulated Chitosan Microsphere for Effective Removal of Reactive Oxygen Species |
| 초록 |
Reactive oxygen species (ROS) have been caused to life-span due to many diseases and aging. The anti-oxidant (AO) used for the removal of ROS has a potential such as Anti-allergic, anti-oxide, anti-cancer effective and Low toxic. However, the disadvantages of AO is that it has a low bioavailability in the body. Therefore, we developed to natural anti-oxidant-encapsulated chitosan microsphere by spray dry method. Its chemical structure was analyzed by 1H-NMR and FT-IR. In addition, morphological property of anti-oxidant agent-encapsulated chitosan microsphere (AECM) was analyzed by SEM and It showed to spherical shape. Beside, particle size of AECM was confirmed to 2 ~ 5 ㎛. Moreover, its cytotoxicity was accomplished by MTT assay. Additionally, encapsulation of anti-oxidant from AECM was confirmed by UV-vis spectrophotometer. These results suggest that AECM can be effectively removed ROS as an antioxidant with low toxicity and improved bioavailability. (NRF-2016H1D5A1910499). |
| 저자 |
홍웅길1, 남충현1, 안준혁1, 정경원1, 박준규2, 나재운1
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| 소속 |
1순천대, 2(주)시지바이오 |
| 키워드 |
Anti-oxidant agent; Chitosan microsphere; Reactive Oxygen Species (ROS); Bioavailability
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| E-Mail |
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