| 초록 |
Thermosensitive poly(organophosphazenes) bearing α-amino-ω-methoxy-poly(ethylene glycol) and hydrophobic L-isoleucine ethyl ester (ILeOEt) as side groups have been synthesized, and their reversible sol-gel properties were investigated by means of 31P-NMR spectroscopy and viscometer. In an aqueous solution, the poly(organophosphazenes) were soluble at low temperature while they form gels at body temperature. The release behavior of model drugs, FITC-Dextran and FITC-Albumin, from the thermosensitive polymer gel was investigated. They were released over 2 weeks in a controlled rate. |
