| 초록 |
Thermosensitive poly(organophosphazenes) bearing α-amino-ω-methoxy-PEG (AMPEG) and hydrophobic L-isoleucine ethyl ester (ILeOEt) as side groups have been synthesized,and their reversible sol-gel properties were investigated by means of 31P NMR spectroscopy, viscometer and GPC. In an aqueous solution, the poly(organophosphazenes) exhibited thermosensitive gelation property. In vitro release behavior and antitumor activity of doxorubicin from the polymer gels were examined. The anticancer agent, doxorubicin, loaded easily in the polymers at low temperature was released over a month from the polymer gels in a controlled rate. |
