| 학회 |
한국고분자학회 |
| 학술대회 |
2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 |
30권 1호, p.675 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Anticancer Drug Release from Biodegradable Thermosensitive Poly(organophosphazene) Gels |
| 초록 |
The new anticancer therapy using localized hydrogel-based drug delivery system was to improve bioavailability and to increase the therapeutic efficacy. We have been synthesized biodegaradable thermosensitive poly(organophosphazene) gels bearing α-amino-ω-methoxy-poly(ethylene glycol), L-isoleucine ethyl ester and glycine lactate ethyl ester as side groups. The poly(organophosphazene) gels were characterized by means of 1H-, 31P-NMR spectroscopies, viscometer and GPC. The anticancer drugs were loaded into the poly(organophosphazene) via physical mixing. The poly(organophosphazene) gels showed in vitro controlled release of anticancer drugs for above 30 days under several conditions. |
| 저자 |
허정윤1, 정성범1, 김지은1, 이선미1, 안철희2, 송수창1
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| 소속 |
1한국과학기술(연), 2서울대 |
| 키워드 |
poly(organophosphazene) gels; hydrogel-based drug delivery system
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| E-Mail |
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