| 초록 |
Treatment of the osteoarthritis (OA) by using corticosteroid (CS) is a common method due to their anti-inflammatory effect. But still, they have drawbacks such as fast clearance and potential side-effect. Therefore, we suggest a sustained delivery of CS which is a prolonged and safe way to intra-articular (IA) cartilage for the inhibition of progressive OA. We developed an IA injectable CS encapsulated polymer nanoparticle that needs only a mixing between CS and polymer and then a single IA injection for the long-term treatment of OA. During mixing, our thermosensitive poly(phosphazene) hydrogel embraces CS to its network by hydrophobic interaction and becomes nano-sized particle structure. This enabled the CS to be slowly released out and had a potent inhibitory effect against OA progression without causing significant side-effects. Taken together, this system can be a decent tool as an IA drug delivery depot for treating OA for a long-term in a safe manner. |
