| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Immobilization of Catechol-Functionalized Polymer Nanoparticles onto Ti Surfaces for Controlled BMP-2 Release |
| 초록 |
Surface engineering with bioactive agents has been widely utilized to promote the performance of medical devices. In particular, the surface immobilization of nanocontainers that can control the release of bioactive molecules has emerged as a promising technique. Herein, we report on a novel nanoparticle bearing Ti-adhesive catechol moieties on its outer periphery. The nanoparticles were prepared by the self-assembly of catechol-terminated polyaspartate-b-polyphenylalanine. The nanoparticles could be successfully immobilized onto Ti surfaces by a simple dipping process without the pre-treatment of Ti surfaces. Their immobilization density could be controlled by adjusting the nanoparticle concentrations. Furthermore, the loading capacity and sustainable release of BMP-2 could be controlled by adjusting the immobilization ratio of nanoparticles. The Ti-adhesive nanoparticle can find many utilities as a surface releasing system for medical devices including stents and dental implants. |
| 저자 |
이홍재, 이상천
|
| 소속 |
경희대 |
| 키워드 |
Ti-adhesive nanoparticle; catechol; surface immobilization; BMP-2; Controlled release
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| E-Mail |
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