| 초록 |
Theranostic nanoparticles, which combine imaging and therapeutic functionalities, have played an important role in the improvement of cancer treatment. We aim to develop a theranostic agent based on doxorubicin (DOX)-loaded MnCO3 nanoparticles (DOX-MnCO3 NPs) that can generate CO2 bubbles and Mn2+ ions for US imaging and T1 imaging, respectively, and simultaneously release DOX for cancer treatment. At physiological pH (7.4), the DOX-MnCO3 NPs would not show noticeable US and T1 MR contrast signals. In contrast, at tumoral pH (6.4), they may generate strong echogenic signals due to CO2 bubble generation and T1 signals caused by the release of Mn2+ ions. In addition, at tumoral pH, the DOX-MnCO3 NPs would effectively release DOX for cancer treatment. This activatable dual contrast agents equipped with drug-releasing property may serve as a novel theranostic nanoparticles for improved diagnosis and therapy of various cancers. |
