| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Evaluation of stability and biocompatibility ; Crosslinked human acellular dermal matrix(SureDermTM) |
| 초록 | Recently, the high viscous filler as xenografts (bovine collagen and hyaluronic acid derivatives), autografts (autologous fat, isolagen, and autologen), homografts (Dermalogen and Sheba), and synthetic materials (fluid silicone and artecoll) has been used in various medical parts. Although a variety of injectable agents are available for soft tissue augmentation, no perfect filler material exists. The advantages and disadvantages of commonly used materials such as bovine collagen have been well reported. However, many newer injectables are still undergoing experimentation to determine their clinical efficacy and long-term safety. Among the commercialized filler, human derived acellular dermal matrix(ADM) has been applied in congenital deformity and traumatic scar usefully, but has a disadvantage of rapid degradation rate (short longevity). Therefore, this study describe the preparation and characterization of cross-linked acelluar dermal matrices(cADM) for improvement of longevity. For cross-linking of ADM, several well-known agents were treated to the collagen fibrils of ADM; glutaraldehyde, 3, 3-dithio propionimidate(DTBP), and 1, 4-butanediol diglycidyl ether. The prepared cADM were characterized its physical properties by differential scanning calorimetry(DSC), universal test machine(UTM), and water-uptake ability. The bio-compatibility and in vivo durability were evaluated by animal test. Acknowledgement: This study was supported by R&D Program for Commom Advanced Technology from Korea Ministry of Commerce, Industry and Energy |
| 저자 | 송석범1, 김진영1, 서석진1, 김태운1, 강계원1, 강낙헌2, 송계용3 |
| 소속 | 1한스바이오메드, 2충남의대 성형외과학교실, 3중앙의대 병리학교실 |
| 키워드 | acellular dermal matrix; injectable |
