| 초록 |
The catechol-modified adhesive hydrogels have been widely studied as they have shown superior biocompatibility and strong adhesives in wet conditions. However, they still have some limitations, such as low conjugation efficiency of catechol onto the polymer backbone and slow oxidation due to the lack of oxygen (O2). Herein, we develop O2-generating gelatin-based hydrogels formed via calcium peroxide (CaO2)-mediated crosslinking and in situ polymerization of dopamine (DA). The oxidation of DA was accelerated by CaO2 mediated-O2 supply, resulting in rapid DA polymerization within the matrices. We demonstrate the hydrogels generated O2 up to 70% pO2 and maintained hyperoxic levels for 7 days in vitro. The hydrogels showed controllable tissue adhesiveness (15−38 kPa). In vivo experiments prove the hydrogels facilitated wound closing rate and the regeneration of the skin appendages. In conclusion, we suggest that our O2-generating hydrogels possess great potential for wound management. |
