| 초록 |
Calcium-alginate hydrogels have received great attentions as scaffolding material because they have low toxicity, good mechanical properties and easily form hydrogel via ionic interaction. However, the major drawback to these systems is rapid dissipation of mechanical properties and degradation by loss of cations. Herein, we developed catechol conjugated alginate hydrogel through EDC/NHS coupling. The mechanical properties of hydrogel were kinetically controlled by two phases of cross-linking.This alginate-catechol hydrogel showed high stability over months in physiological condition even after calcium ions dissociated as time passed and elastic modulus (G’) was continuously maintained, which cannot be achieved in ionic hydrogels. As potential application, alginate hydrogel was manufactured in 3-D scaffold and cytotoxicity test was also performed. This hydrogel may enhance the potential for biomedical applications such as tissue engineering. |
