| 학회 | 한국화학공학회 |
| 학술대회 | 2012년 가을 (10/24 ~ 10/26, 부산 BEXCO) |
| 권호 | 18권 2호, p.1739 |
| 발표분야 | 분리기술 |
| 제목 | Monitoring of Indomethacin-Saccharin Cocrystal Formation Using Anti-solvent Co-crystallization Process by in-line Near-infrared (NIR) Spectroscopy |
| 초록 | Pharmaceutical cocrystal has attracted much attention due to the potential for improved physicochemical properties such as solubility, stability and dissolution behavior. In our recent experiment, we prepared IMC-SAC cocrystal using anti-solvent crystallization method. The purpose of this study was to examine NIR spectroscopy as a PAT tool to monitor the formation of indomethacin(IMC) and saccharin(SAC) cocrystals via anti-solvent co-crystallization process. The whole process of IMC-SAC cocrystal formation and growth was monitored in real- time with fiber-optic NIR probe and the collected NIR data were analyzed using the multivariate analysis. Also, off-line characterization using powder X-ray diffraction, differential scanning calorimetry and particle size analyzer was performed to comprehensively interpret the whole process combine with the multivariate analysis results. |
| 저자 | 이민정1, 왕인천1, 천난희1, 최광진2 |
| 소속 | 1인제대, 2순천향대 |
| 키워드 | cocrystal; indomethacin; saccharin; anti-solvent cocrystallization; near-infrared(NIR) spectroscopy |
| VOD | VOD 보기 |
| 원문파일 | 초록 보기 |
