| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Initial burst controlled drug delivery formulation of microcapsules |
| 초록 |
Here we describe the preparation of BSA-FITC-loaded microcapsules mixed with various thermo-sensitive hydrogels as controlled release system. Microcapsules consisting of a BSA-FITC core and a PLGA shell were prepared by using a mono-axial nozzle ultrasonic atomizer. The thermo-sensitive hydrogel were prepared by using aqueous solutions of MPEG-PCL, Pluronic and chitosan. The hydrogel containing microcapsules was subcutaneously injected to a rat. To determine in vivo BSA-FITC release, each formulation of BSA-FITC-loaded microcapsules in the presence of various hydrogels was monitored in vivo over time by measuring plasma BSA-FITC in rats. The hydrogel containing microcapsules showed delayed maximum of BSA-FITC, and in addition exhibited a sustained-release profile in plasma for up to 7 weeks. Therefore, the formulation in this work was prepared by relatively simple process and allowed a BSA to be released at a constant rate with minimized initial burst for a long period of time. |
| 저자 |
김다연, 강꽃님, 권진선, 서효원, 김재호, 김문석
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| 소속 |
아주대 |
| 키워드 |
microcapsules; thermo-sensitive hydrogels; drug delivery
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| E-Mail |
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